Selective detection of fluorophore layers in turbid media: the role of fiber-optic probe design

被引：61

作者：

Pfefer, TJ ^{[1
]}

Matchette, LS ^{[1
]}

Ross, AM ^{[1
]}

Ediger, MN ^{[1
]}

机构：

[1] US FDA, Ctr Devices & Radiol Hlth, Rockville, MD 20857 USA

来源：

OPTICS LETTERS | 2003年 / 28卷 / 02期

关键词：

D O I：

10.1364/OL.28.000120

中图分类号：

O43 [光学];

学科分类号：

070207 [光学]; 0803 [光学工程];

摘要：

Experimental verification of the ability to alter the sensitivity to fluorophore layers in turbid media by varying illumination-collection geometry is presented. Fiber-optic probes and two-layer, fluorophore-doped, turbid phantoms are used to elucidate the roles of spot size, illumination-collection fiber separation, and probe-sample spacing. Variations in single-and multiple-fiber probe design parameters produce significant changes in the relative sensitivity to sample layers in a manner that agrees with prior computational studies. (C) 2003 Optical Society of America.

引用

页码：120 / 122

页数：3

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