The moderation by the serotonin transporter gene of environmental adversity in the etiology of depression: 2009 update

被引：300

作者：

Uher, R. ^{[1
]}

McGuffin, P. ^{[1
]}

机构：

[1] Kings Coll London, Social Genet & Dev Psychiat Ctr, Inst Psychiat, London SE5 8AF, England

来源：

MOLECULAR PSYCHIATRY | 2010年 / 15卷 / 01期

基金：

英国医学研究理事会;

关键词：

gene-environment interactions; serotonin transporter; depression; stressful life events; adversity; adolescence; STRESSFUL LIFE EVENTS; POLYMORPHISM; 5-HTTLPR; INTERVIEW METHODS; ASSOCIATION; RISK; PSYCHOPATHOLOGY; ANXIETY; ADULTS;

D O I：

10.1038/mp.2009.123

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An updated review of 34 human observational studies indicates that the length polymorphism of the serotonin transporter gene moderates the effect of environmental adversity in the development of depression. This finding depends on the use of contextual or objective methods to assess environmental adversity and is attenuated when self-report instruments are used. Inconsistent findings in male adolescents suggest a developmental stage and sex-specific protective mechanism. These systematic relationships between method and results should be followed up to specify causal mechanisms leading to depression. Molecular Psychiatry (2010) 15, 18-22; doi: 10.1038/mp.2009.123

引用

页码：18 / 22

页数：5

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