Novel functions of TIMPs in cell signaling

被引：387

作者：

Chirco, R ^{[1
]}

Liu, XW ^{[1
]}

Jung, KK ^{[1
]}

Kim, HRC ^{[1
]}

机构：

[1] Wayne State Univ, Sch Med, Barbara Ann Karmanos Canc Inst, Dept Pathol, Detroit, MI 48201 USA

来源：

CANCER AND METASTASIS REVIEWS | 2006年 / 25卷 / 01期

关键词：

extracellular matrix (ECM); matrix metalloproteinase (MMP); tissue inhibitor of metalloproteinase (TIMP); apoptosis; tetraspanin; integrin;

D O I：

10.1007/s10555-006-7893-x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Tissue inhibitors of metalloproteinases (TIMPs) are endogenous inhibitors of matrix metalloproteinases (MMPs) and the balance between MMPs/TIMPs regulates the extracellular matrix (ECM) turnover and remodeling during normal development and pathogenesis. Increasing evidence indicates a much more complex role for TIMPs during tumor progression and angiogenesis, in addition to their regulation of MMP-mediated ECM degradation. In this article, we review both the MMP-dependent and -independent actions of TIMPs for the regulation of cell death, cell proliferation, and angiogenesis, with a particular emphasis on TIMP-1 in the regulation of tetraspanin/integrin-mediated cell survival signal transduction pathways.

引用

收藏

页码：99 / 113

页数：15

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