Regulation of stroke-induced neurogenesis in adult brain - Recent scientific progress

被引：82

作者：

Kokaia, Zaal ^{[1
]}

Thored, Par

Arvidsson, Andreas

Lindvall, Olle

机构：

[1] Univ Hosp, Stem Cell Inst, Sect Restorat Neurol, Lab Neural Stem Cell Biol, SE-22184 Lund, Sweden

[2] Lund Strateg Res Ctr Stem Cell Biol & Cell Therap, Lund, Sweden

[3] Univ Hosp, Wallenberg Neurosci Ctr, Sect Restorat Neurol, Lab Neurogenesis & Cell Therapy, SE-22184 Lund, Sweden

来源：

CEREBRAL CORTEX | 2006年 / 16卷

关键词：

migration; neural stem cells; neurogenesis; striatum; stroke; subventricular zone;

D O I：

10.1093/cercor/bhj174

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Stroke induced by middle cerebral artery occlusion in adult rodents induces the formation of new neurons in the damaged striatum, a region that normally does not show neurogenesis. Here we describe recent findings on the regulation of neurogenesis after stroke, in particular regarding the duration of the neurogenic response and the influence of age, as well as the molecular mechanisms influencing migration and survival of the new neurons. We also discuss some crucial issues that need to be addressed in the further exploration of this potential self-repair mechanism after damage to the adult brain.

引用

收藏

页码：I162 / I167

页数：6

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