Boning up on ephrin signaling

被引：141

作者：

Mundy, Gregory R. ^{[1
]}

Elefteriou, Florent ^{[1
]}

机构：

[1] Vanderbilt Univ, Med Ctr, Vanderbilt Ctr Bone Biol, Nashville, TN 37212 USA

来源：

CELL | 2006年 / 126卷 / 03期

关键词：

D O I：

10.1016/j.cell.2006.07.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The activities of osteoclasts, which degrade bone, and osteoblasts, which form bone, are coordinated to maintain bone homeostasis. Zhao et al. (2006) now demonstrate bidirectional signaling between these two cell populations via the transmembrane ligand ephrinB2 expressed by osteoclasts and its receptor Ephl34 expressed by osteoblasts. Such bidirectional signaling limits osteoclast activity while stimulating osteoblast differentiation.

引用

页码：441 / 443

页数：3

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