Effect of curcurnin on gelatinase A (MMP-2) activity in B16F10 melanoma cells

被引：70

作者：

Banerji, A ^{[1
]}

Chakrabarti, J ^{[1
]}

Mitra, A ^{[1
]}

Chatterjee, A ^{[1
]}

机构：

[1] Chittaranjan Natl Canc Inst, Dept Receptor Biol & Tumor Metastasis, Kolkata 700026, W Bengal, India

来源：

CANCER LETTERS | 2004年 / 211卷 / 02期

关键词：

curcumin; focal adhesion kinase; integrin; metastasis; MMP-2;

D O I：

10.1016/j.canlet.2004.02.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Treatment of highly metastatic murine melanoma cells B16F10 with curcumin (15 muM) for 15 days significantly inhibited matrixmetalloproteinase-2 (MMP-2) activity. Expression of membrane type-1 matrixmetalloproteinase (MT1-MMP) and focal adhesion kinase (FAK), an important component of the intracellular signalling pathway, were also reduced to almost background levels. MMP-2, MT1-MMP and FAK did not return to control levels even after 28 days of drug withdrawal. However, effect of curcumin on ligand binding property of integrin receptors was reversible. Downregulation of FAK (which would impair integrin mediated signal transduction cascade) and reduction of MMP-2 activity could be important reasons for anti-metastatic property of curcumin. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：235 / 242

页数：8

共 34 条

[1] ANALYSIS OF FIBRONECTIN RECEPTOR FUNCTION WITH MONOCLONAL-ANTIBODIES - ROLES IN CELL-ADHESION, MIGRATION, MATRIX ASSEMBLY, AND CYTOSKELETAL ORGANIZATION [J].