Increased serum oxidative stress in patients with severe mitral regurgitation: A new finding and potential mechanism for atrial enlargement

被引：20

作者：

Chen, Mien-Cheng ^{[1
]}

Chang, Jen-Ping ^{[2
]}

Liu, Wen-Hao ^{[1
]}

Yang, Cheng-Hsu ^{[1
]}

Chen, Chien-Jen ^{[1
]}

Fang, Chih-Yuan ^{[1
]}

Hsieh, Yuan-Kai ^{[1
]}

Wang, Ya-Hui ^{[1
]}

Chang, Hsueh-Wen ^{[3
]}

机构：

[1] Chang Gung Univ, Coll Med, Chang Gung Mem Hosp, Kaohsiung Med Ctr,Dept Internal Med,Div Cardiol, Kaohsiung Hsien 83301, Taiwan

[2] Chang Gung Univ, Coll Med, Chang Gung Mem Hosp, Kaohsiung Med Ctr,Div Cardiovasc Surg, Kaohsiung Hsien 83301, Taiwan

[3] Natl Sun Yat Sen Univ, Dept Biol Sci, Kaohsiung, Taiwan

来源：

CLINICAL BIOCHEMISTRY | 2009年 / 42卷 / 10-11期

关键词：

Atrial fibrillation; Mitral valve insufficiency; Oxidative stress; VALVE DISEASE; FIBRILLATION; STRETCH; HEART;

D O I：

10.1016/j.clinbiochem.2009.04.012

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Objective: The aim of this study was to examine the serum oxidative stress in patients with severe mitral regurgitation. Design and methods: This study analyzed serum oxidative stress index in patients with severe mitral regurgitation [persistent atrial fibrillation (AF) or sinus rhythm], paroxysmal lone AF patients and healthy subjects. Results: The serum oxidative stress index was significantly higher in the mitral regurgitation AF group and sinus group than in the lone AF group and healthy subjects (p < 0.0001). Left atrial size was significantly larger in the mitral regurgitation AF group and sinus group than in the lone AF group and healthy subjects (p < 0.0001). The oxidative stress index significantly and positively correlated with left atrial size in the overall study population (r=0.439, p=0.0008). Conclusions: This study provides new evidence of increased oxidative stress in human severe mitral regurgitation, probably contributing to atrial enlargement. (c) 2009 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

引用

页码：943 / 948

页数：6

共 24 条

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