Genomics meets HIV-1

被引：47

作者：

Telenti, Amalio ^{[1
]}

Goldstein, David B.

机构：

[1] Univ Lausanne, Univ Hosp, Inst Microbiol, CH-1011 Lausanne, Switzerland

[2] Duke Univ, Inst Genome Sci & Policy, Ctr Populat Genom & Pharmacogenet, Durham, NC 27708 USA

[3] Duke Univ, Ctr HIV AIDS Vaccine Immunol, Durham, NC 27708 USA

来源：

NATURE REVIEWS MICROBIOLOGY | 2006年 / 4卷 / 11期

关键词：

D O I：

10.1038/nrmicro1532

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Genomics is now a core element in the effort to develop a vaccine against HIV-1. Thanks to unprecedented progress in high-throughput genotyping and sequencing, in knowledge about genetic variation in humans, and in evolutionary genomics, it is finally possible to systematically search the genome for common genetic variants that influence the human response to HIV-1. The identification of such variants would help to determine which aspects of the response to the virus are the most promising targets for intervention. However, a key obstacle to progress remains the scarcity of appropriate human cohorts available for genomic research.

引用

页码：865 / 873

页数：9

共 78 条

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