Computational characterization of multiple Gag-like human proteins

被引：120

作者：

Campillos, Monica ^{[1
]}

Doerks, Tobias ^{[1
]}

Shah, Parantu K. ^{[1
]}

Bork, Peer ^{[1
]}

机构：

[1] European Mol Biol Lab, D-69117 Heidelberg, Germany

来源：

TRENDS IN GENETICS | 2006年 / 22卷 / 11期

关键词：

D O I：

10.1016/j.tig.2006.09.006

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学]; 090102 [作物遗传育种];

摘要：

In a genome-wide analysis, we have identified 85 human genes encoding 103 protein isoforms that resemble retroviral Gag proteins. These genes were domesticated from retrotransposons in at least five independent events during vertebrate evolution and were subsequently duplicated further in mammals. Structural insights into the mammalian proteins can be inferred by homology to Gag from viruses such as HIV; in turn, the cellular roles of the mammalian Gag homologs, such as apoptosis-related functions and binding to ubiquitin ligases, might hint at further functionality of viral Gag itself.

引用

页码：585 / 589

页数：5

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