Potassium channel openers: The case of BK channel activators

被引：18

作者：

Nardi, A.

Calderone, V.

Olesen, S. -P.

机构：

[1] NeuroSearch AS, Dept Chem, DK-2750 Ballerup, Denmark

[2] Univ Pisa, Dipartimento Psichiat Neurobiol Farmacol & Biotec, I-56126 Pisa, Italy

[3] Univ Copenhagen, Panum Inst, Dept Med Physiol, DK-2200 Copenhagen N, Denmark

[4] Danish Natl Res Fdn, Ctr Cardiac Arrhythmia Res, DK-2200 Copenhagen N, Denmark

[5] NeuroSearch AS, Dept Ion Channel Physiol, DK-2750 Ballerup, Denmark

来源：

LETTERS IN DRUG DESIGN & DISCOVERY | 2006年 / 3卷 / 04期

关键词：

potassium channels; BK-channels; Maxi-K channels; drug design; BK channel activator; synthesis;

D O I：

10.2174/157018006776743242

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Large-conductance calcium-activated potassium channels, also known as BK or Maxi-K channels, occur in many types of cells, where they play an essential role in the regulation of cell excitability and function. BK channel openers constitute a heterogeneous group of organic compounds being able to activate BK channels and having a wide therapeutic potential for the treatment of different neurological, urological and cardiovascular diseases. This review addresses the novel research on BK channels as drug targets as well as it reports recent developments in the chemistry of BK channel openers and in the chemical structural aspects determining their activity.

引用

页码：210 / 218

页数：9

共 120 条

[1] Stable expression of the human large-conductance Ca2+-activated K+ channel alpha- and beta-subunits in HEK293 cells [J].