Preliminary screening of some traditional zulu medicinal plants for anti-inflammatory and anti-microbial activities

Aqueous and methanolic extracts from different parts of nine traditional Zulu medicinal plants, of the Vitaceae from KwaZulu-Natal, South Africa were evaluated for therapeutic potential as anti-inflammatory and anti-microbial agents. Of the twenty-nine crude extracts assayed for prostaglandin synthesis inhibitors, only five methanolic extracts of Cyphostemma natalitium-root, Rhoicissus digitata-leaf, Ii. rhomboidea-root, Ii. tomentosa-leaf/stem and Ii. tridentata-root showed significant inhibition of cyclo-oxygenase (COX-I). The extracts of Ii. digitata-leaf and of Ii. rhomboidea-root exhibited the highest inhibition of prostaglandin synthesis with 53 and 56%, respectively. The results suggest that Rhoicissus digitata leaves and of Rhoicissus rhomboidea roots may have the potential to be used as anti-inflammatory agents. All the screened plant extracts showed some degrees of anti-microbial activity against Gram-positive and Gram-negative microorganisms. The methanolic extracts of C. natalitium-stem and root, Ii. rhomboidea-root, and Ii. tomentosa-leaf/stem, showed different anti-microbial activities against almost all micro-organisms tested. Generally, these plant extracts inhibited the Gram-positive micro-organisms more than the Gram-negative ones. Several plant extracts inhibited the growth of Candida albicans while only one plant extract showed inhibitory activity against Saccharomyces cerevisiae. All the plant extracts which demonstrated good anti-inflammatory activities also showed better inhibitory activity against Candida albicans. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.