The significance of cancer cell expression of the chemokine receptor CXCR4

被引：629

作者：

Balkwill, F ^{[1
]}

机构：

[1] Barts & London Queen Marys Med Sch, Translat Oncol Lab, London EC1M 6BQ, England

来源：

SEMINARS IN CANCER BIOLOGY | 2004年 / 14卷 / 03期

关键词：

CXCR4; CXCL12; metastasis; invasion;

D O I：

10.1016/j.semcancer.2003.10.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Malignant cells from at least 23 different types of cancer express the chemokine receptor CXCR4 and respond to its ligand CXCL12. This receptor ligand pair appears to be involved in directed migration of cancer cells to sites of metastasis, increased survival of cancer cells in sub optimal conditions and establishment of a tumour promoting cytokine/chemokine network. Preliminary data from animal models suggest that CXCR4 may be an important therapeutic target in a range of cancers. However CXCR4 plays major roles in embryogenesis, homeostasis and inflammation. This raises questions concerning the specificity of CXCR4 antagonists in the treatment of cancer. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：171 / 179

页数：9

共 97 条

[1] The chemokine SDF-1 is a chemoattractant for human CD34(+) hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34(+) progenitors to peripheral blood [J].

Aiuti, A ;

Webb, IJ ;

Bleul, C ;

Springer, T ;

GutierrezRamos, JC .

JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 185 (01) :111-120

[2] The chemokine receptor switch paradigm and dendritic cell migration: its significance in tumor tissues [J].

Allavena, P ;

Sica, A ;

Vecchi, A ;

Locati, M ;

Sozzani, S ;

Mantovani, A .

IMMUNOLOGICAL REVIEWS, 2000, 177 :141-149

[3] Impaired colonization of the gonads by primordial germ cells in mice lacking a chemokine, stromal cell-derived factor-1 (SDF-1) [J].

Ara, T ;

Nakamura, Y ;

Egawa, T ;

Sugiyama, T ;

Abe, K ;

Kishimoto, T ;

Matsui, Y ;

Nagasawa, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (09) :5319-5323

[4]

Bachelder RE, 2002, CANCER RES, V62, P7203

[5] Chemokine biology in cancer [J].

Balkwill, F .

SEMINARS IN IMMUNOLOGY, 2003, 15 (01) :49-55

[6]

Barbero S, 2003, CANCER RES, V63, P1969

[7] Expression of the chemokine receptor CXCR4 and its ligand stromal cell-derived factor 1 in human brain tumors and their involvement in glial proliferation in vitro [J].

Barbero, S ;

Bajetto, A ;

Bonavia, R ;

Porcile, C ;

Piccioli, P ;

Pirani, P ;

Ravetti, JL ;

Zona, G ;

Spaziante, R ;

Florio, T ;

Schettini, G .

CELL SIGNALING, TRANSCRIPTION, AND TRANSLATION AS THERAPEUTIC TARGETS, 2002, 973 :60-69

[8] Antigenically distinct conformations of CXCR4 [J].

Baribaud, F ;

Edwards, TG ;

Sharron, M ;

Brelot, A ;

Heveker, N ;

Price, K ;

Mortari, F ;

Alizon, M ;

Tsang, M ;

Doms, RW .

JOURNAL OF VIROLOGY, 2001, 75 (19) :8957-8967

[9]

BARRETINA J, 2003, ANN HEMATOL, P29

[10]

Bertolini F, 2002, CANCER RES, V62, P3106

← 1 2 3 4 5 6 7 8 9 10 →