NTS catecholamine cell recruitment by hemorrhage and hypoxia

被引：33

作者：

Buller, KM ^{[1
]}

Smith, DW ^{[1
]}

Day, TA ^{[1
]}

机构：

[1] Univ Queensland, Dept Physiol & Pharmacol, Brisbane, Qld 4072, Australia

来源：

NEUROREPORT | 1999年 / 10卷 / 18期

关键词：

A2 noradrenergic cells; C2 adrenergic cells; catecholamine cells; hemorrhage; nucleus tractus solitarius; systemic hypoxia;

D O I：

10.1097/00001756-199912160-00024

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

IMMUNOLABELLING for Fos and tyrosine hydroxylase was used to determine the patterns of activation of nucleus tractus solitarius catecholamine cells in response to graded levels of hemorrhage (0, 4, 8, 12 and 16 ml/kg) and systemic hypoxia (21, 14, 12, 10 and 8% O-2) in conscious rats. Both stimuli elicited graded catecholamine cell recruitment with thresholds of 8 ml/kg and 12% O-2. The majority of responsive neurons were A2 noradrenergic rather than C2 adrenergic cells. After hemorrhage most Fos-positive catecholamine cells were found below obex whereas most hypoxia-responsive cells were rostral to obex. These distinctive patterns of catecholamine cell recruitment may explain the differences in neuroendocrine responses to these stimuli. (C) 1999 Lippincott Williams & Wilkins.

引用

页码：3853 / 3856

页数：4

共 27 条

[1] DISTRIBUTION OF HYPOTHALAMIC, MEDULLARY AND LAMINA TERMINALIS NEURONS EXPRESSING FOS AFTER HEMORRHAGE IN CONSCIOUS RATS [J].

BADOER, E ;

MCKINELY, MJ ;

OLDFIELD, BJ ;

MCALLEN, RM .

BRAIN RESEARCH, 1992, 582 (02) :323-328

[2] Differential recruitment of hypothalamic neuroendocrine and ventrolateral medulla catecholamine cells by non-hypotensive and hypotensive hemorrhages [J].

Buller, KM ;

Smith, DW ;

Day, TA .

BRAIN RESEARCH, 1999, 834 (1-2) :42-54

[3] HEMODYNAMIC REGULATION OF TYROSINE-HYDROXYLASE MESSENGER-RNA IN MEDULLARY CATECHOLAMINE NEURONS - A C-FOS-GUIDED HYBRIDIZATION HISTOCHEMICAL-STUDY [J].

CHAN, RKW ;

SAWCHENKO, PE .

NEUROSCIENCE, 1995, 66 (02) :377-390

[4] BRAIN-STEM PROJECTIONS OF AORTIC BARORECEPTOR AFFERENT-FIBERS IN THE RAT [J].

CIRIELLO, J .

NEUROSCIENCE LETTERS, 1983, 36 (01) :37-42

[5] ANATOMICAL SPECIFICITY OF NORADRENERGIC INPUTS TO THE PARAVENTRICULAR AND SUPRAOPTIC NUCLEI OF THE RAT HYPOTHALAMUS [J].

CUNNINGHAM, ET ;

SAWCHENKO, PE .

JOURNAL OF COMPARATIVE NEUROLOGY, 1988, 274 (01) :60-76

[6] ELECTROPHYSIOLOGICAL EVIDENCE THAT NORADRENERGIC AFFERENTS SELECTIVELY FACILITATE THE ACTIVITY OF SUPRAOPTIC VASOPRESSIN NEURONS [J].

DAY, TA ;

RENAUD, LP .

BRAIN RESEARCH, 1984, 303 (02) :233-240

[7] HEMORRHAGE INDUCES FOS IMMUNOREACTIVITY IN RAT MEDULLARY CATECHOLAMINERGIC NEURONS [J].

DUN, NJ ;

DUN, SL ;

CHIAIA, NL .

BRAIN RESEARCH, 1993, 608 (02) :223-232

[8] HYPOXIA AND ELECTRICAL-STIMULATION OF THE CAROTID-SINUS NERVE INDUCE FOS-LIKE IMMUNOREACTIVITY WITHIN CATECHOLAMINERGIC AND SEROTONINERGIC NEURONS OF THE RAT BRAIN-STEM [J].

ERICKSON, JT ;

MILLHORN, DE .

JOURNAL OF COMPARATIVE NEUROLOGY, 1994, 348 (02) :161-182

[9] THE CENTRAL ORGANIZATION OF CAROTID-BODY AFFERENT-PROJECTIONS TO THE BRAIN-STEM OF THE RAT [J].

FINLEY, JCW ;

KATZ, DM .

BRAIN RESEARCH, 1992, 572 (1-2) :108-116

[10] THE N-METHYL-D-ASPARTATE RECEPTOR PATHWAY IS INVOLVED IN HYPOXIA-INDUCED C-FOS PROTEIN EXPRESSION IN THE RAT NUCLEUS OF THE SOLITARY TRACT [J].

HAXHIU, MA ;

STROHL, KP ;

CHERNIACK, NS .

JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM, 1995, 55 (1-2) :65-68

← 1 2 3 →