Staphylococcus aureus Nasal Carriage Among Patients and Health Care Workers in Sao Tome and Principe

被引：35

作者：

Conceicao, Teresa ^{[1
]}

Silva, Isabel Santos ^{[2
]}

de Lencastre, Herminia ^{[1
,3
]}

Aires-de-Sousa, Marta ^{[2
]}

机构：

[1] Univ Nova Lisboa, Inst Tecnol Quim & Biol, Mol Genet Lab, P-2780156 Oeiras, Portugal

[2] Escola Super Saude da Cruz Vermelha Portuguesa ES, Lisbon, Portugal

[3] Rockefeller Univ, Microbiol Lab, New York, NY 10021 USA

来源：

MICROBIAL DRUG RESISTANCE | 2014年 / 20卷 / 01期

关键词：

VALENTINE LEUKOCIDIN GENES; FIELD GEL-ELECTROPHORESIS; SOFT-TISSUE INFECTIONS; METHICILLIN-RESISTANT; ANTIMICROBIAL SUSCEPTIBILITY; MOLECULAR EPIDEMIOLOGY; POPULATION-STRUCTURE; SKIN INFECTIONS; HIGH PREVALENCE; MULTIPLEX PCR;

D O I：

10.1089/mdr.2013.0136

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Methicillin-resistant Staphylococcus aureus (MRSA) is a major human pathogen worldwide. However, data on MRSA prevalence in the African continent are scarce and nonexistent for SAo Tome and Principe. In November 2010 and April 2012, a total of 332 individuals (258 patients and 74 health care workers [HCW]) from Hospital Dr. Ayres Menezes in SAo Tome and Principe, were screened for S. aureus and MRSA carriage. Fifty-two persons (15.7%) were S. aureus nasal carriers out of which 14 (26.9%) were colonized with MRSA. MRSA isolates belonged to three clonal complexes: CC8 (PFGE type B-ST8-t064/t451-IVg/V), CC88 (PFGE E-ST88-t186/t786-IVa), and CC5 (PFGE K-ST5-t105-IVa/PFGE K-ST105-t002-II). A higher genetic diversity was found among methicillin-susceptible S. aureus (MSSA) isolates where 58.5% (n=24) belonged to four major lineages: PFGE type A-ST15-t084; PFGE C-ST508-t861 or related; PFGE D-ST152-t355 or related; and PFGE G-ST121-t159/t2304. Despite the common nonmultiresistant profile, 98% of the isolates harbored two or more virulence factors. Panton-Valentine leukocidine was detected in 36% of the isolates, all MSSA. S. aureus cross-transmission between HCW and patients in the pediatric and medicine wards and the detection of identical MRSA strains among patients in two different wards evidenced the need of implementation of additional infection control measures in this hospital.

引用

页码：57 / 66

页数：10

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