Multicomponent synthesis of 3-heteroarylpropionic acids

被引：46

作者：

Adamo, Mauro F. A. ^{[1
]}

Duffy, Eleanor F. ^{[1
]}

机构：

[1] Royal Coll Surgeons Ireland, Dept Pharmaceut & Med Chem, CSCB, Dublin 2, Ireland

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 22期

关键词：

D O I：

10.1021/ol062151y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A four component one-pot procedure (4-MC) was developed to assemble 3-heteroarylpropionic acids from commercially available materials. This new methodology affords the title compounds in high yields and without the use of chromatography.

引用

页码：5157 / 5159

页数：3

共 11 条

[1] Multicomponent synthesis of spiroisoxazolines [J].

Adamo, MFA ;

Donati, D ;

Duffy, EF ;

Sarti-Fantoni, P .

JOURNAL OF ORGANIC CHEMISTRY, 2005, 70 (21) :8395-8399

[2] Application of bis-acetylenic ketones in synthesis: One-pot preparation of the 1,2,4-triazepine and oxatriazaindenone cores [J].

Adamo, MFA ;

Baldwin, JE ;

Adlington, RM .

JOURNAL OF ORGANIC CHEMISTRY, 2005, 70 (08) :3307-3308

[3] The reactivity of 3-methyl-4-nitro-5-styrylisoxazole with some bis-enolisable ketones [J].

Adamo, MFA ;

Chimichi, S ;

De Sio, F ;

Donati, D ;

Sarti-Fantoni, P .

TETRAHEDRON LETTERS, 2002, 43 (23) :4157-4160

[4]

ANDERSON K, 1999, Patent No. 19990531

[5]

BARACCHI A, 1986, HETEROCYCLES, V24, P2863

[6]

CHIMICHI S, 1983, HETEROCYCLES, V20, P263

[7]

FLYNN DL, 2006, Patent No. 47597

[8]

GILCHRIST TL, 1997, HETEROCYCLIC CHEM, P61

[9]

KRISHNA KSR, 1976, P INDIAN ACAD SCI A, V84, P79

[10] Catalytic asymmetric synthesis with Rh-diene complexes: 1,4-addition of arylboronic acids to unsaturated esters [J].

Paquin, JF ;

Stephenson, CRJ ;

Defieber, C ;

Carreira, EM .

ORGANIC LETTERS, 2005, 7 (17) :3821-3824

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