Cellular distribution of the NMDA receptor NR2A/2B subunits in the rat striatum

被引:60
作者
Chen, Q [1 ]
Reiner, A [1 ]
机构
[1] UNIV TENNESSEE, DEPT ANAT & NEUROBIOL, MEMPHIS, TN 38163 USA
关键词
excitatory amino acid; neurodegenerative disease; NMDA; receptor; immunocytochemistry; striatum;
D O I
10.1016/S0006-8993(96)01098-0
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Using immunohistochemical double-labeling with a specific antibody recognizing both NR2A and NR2B subunits, we studied the cellular distribution of the NMDA receptor subunit NR2A/2B on all major known striatal neuron types. Among striatal interneurons, our results showed that none of somatostatin interneurons was labeled for NR2A/2B subunits, 56% of parvalbumin interneurons were double-labeled for NR2A/2B, and all identified cholinergic interneurons were labeled for NR2A/2B. Among striatal projection neurons, 95% of striatonigral neurons, 96% of enkephalin-containing neurons, and 98% of calbindin-containing striatal matrix neurons were double-labeled for NR2A/2B. Our studies demonstrate that there is a differential distribution of the NMDA receptor NR2A/2B subunits on striatal neuron types. The paucity of NR2A/2B subunits on NMDA. receptors on striatal somatostatin interneurons may confer resistance to NMDA receptor-mediated excitotoxicity on these neurons.
引用
收藏
页码:346 / 352
页数:7
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