STAT6 specific shRNA inhibits proliferation and induces apoptosis in colon cancer HT-29 cells

被引：29

作者：

Zhang, Mingsheng

Zhou, Yunfeng

Xie, Conghua

Zhou, Fuxiang

Chen, Yun

Han, Guang

Zhang, Wen Jie

机构：

[1] Wuhan Univ, Zhongnam Hosp & Canc Res Ctr, Dept Canc Radio Chemotherapy, Wuhan 430071, Peoples R China

[2] Wuhan Univ, Sch Med, Med Res Ctr, Key Lab Allergy & Immune Related Dis, Wuhan 430071, Peoples R China

来源：

CANCER LETTERS | 2006年 / 243卷 / 01期

基金：

中国国家自然科学基金;

关键词：

apoptosis; colon cancer; RNA interference; shRNA; STAT6;

D O I：

10.1016/j.canlet.2005.11.020

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

RNA interference (RNAi) has been employed as an effective tool for studying gene functions. Here, we have demonstrated that different short hairpin RNAs (shRNAs) can specifically knock-down the transcription of STAT6, resulting in the inhibition of cell proliferation, G1/S phase arrest and apoptotic death in colon cancer HT-29 cells. These findings suggest that Stat6 signaling pathway plays a role in the regulation of cell proliferation and apoptosis in colon cancer cells, which promises further investigation for targeted cancer therapy. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

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页码：38 / 46

页数：9

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