Hyponatremia in patients with nocturnal enuresis treated with DDAVP

Treatment of nocturnal enuresis with DDAVP is associated with a low incidence of adverse effects. The only reported serious adverse effect is seizure or altered level of consciousness due to water intoxication. We reviewed 14 articles that reported data on serum sodium in patients treated with DDAVP for nocturnal enuresis and 11 articles that reported patients who developed a seizure or altered level of consciousness during treatment with DDAVP for nocturnal enuresis. Excess fluid intake was identified as a contributing factor in 6 of the 11 case reports. Conclusion Hyponatremia is a potential adverse effect inpatients with nocturnal enuresis who are treated with DDAVP, To prevent this adverse effect, we recommend that the patients prescribed DDAVP for nocturnal enuresis should be led not to ingest more than 40 ml (8 ounces) of fluid on any night that DDAVP is administered.