Anti aldol reactions of alpha-alkoxymethyl ketones: Application to the total synthesis of (+)-restricticin.

被引：30

作者：

Paterson, I

Nowak, T

机构：

[1] University Chemical Laboratory, Cambridge CB2 1EW, Lensfield Road

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 45期

关键词：

D O I：

10.1016/0040-4039(96)01879-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The antifungal agent (+)-restricticin (1) was prepared in 12 steps from ketone (S)-8. The key steps are (i) the boron-mediated anti aldol reaction of (S)-8 with 9 to give 13 and (ii) the cyclisation reaction 4->5. Copyright (C) 1996 Elsevier Science Ltd.

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页码：8243 / 8246

页数：4

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