Urinary leukotriene E(4) levels increase upon exposure to hypobaric hypoxia

被引:13
作者
Roach, JM
Muza, SR
Rock, PB
Lyons, TP
Lilly, CM
Drazen, JM
Cymerman, A
机构
[1] USA,ENVIRONM MED RES INST,ALTITUDE PHYSIOL & MED DIV,NATICK,MA 01760
[2] BRIGHAM & WOMENS HOSP,DEPT MED,COMBINED PROGRAM PULM & CRIT CARE MED,BOSTON,MA 02115
[3] HARVARD UNIV,SCH MED,BOSTON,MA
关键词
altitude; altitude sickness; leukotrienes;
D O I
10.1378/chest.110.4.946
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Study objective: To determine whether urinary leukotriene E(4) (uLTE(4)) levels increase upon exposure to high altitude, and also to ascertain the relationship between uLTE(4) levels and symptoms of acute mountain sickness (AMS). Design: Prospective, unblinded, single-factor altitude) experimental study. Settings: US Army research laboratory facilities at sea level ([SL] 50 m), 1,830 m, and 4,300 m. Participants: Eight healthy male subjects ranging in age from 19 to 24 years. Measurements: uLTE(4) levels and symptoms of AMS were measured at just above SL (50 m), 3 1/2 days after being transported from SL to moderate altitude (MA) (1,830 m), and 1 1/2 days after ascent from 1,830 to 4,300 m high altitude [HA]). Symptoms of AMS were assessed using standard indexes derived from he Environmental Symptoms Questionnaire weighted toward cerebral (AMS-C) and respiratory (AMS-R) manifestations. Oxygen saturation was measured noninvasively by pulse oximetry at SL and HA. Results: The mean (+/-SEM) uLTE(4) levels (pg/mg creatinine) were 67.9 (+/-13.2) at SL; 82.3 (+/-5.5) at MA; and 134.8 (+/-19.4) at HA (p<0.05 comparing HA with SL and MA). Conclusions: We conclude that uLTE(4) levels increase shortly after exposure to HA even after staging for 4 days at MA. Although this study does not clearly demonstrate a relationship between uLTE(4) levels and symptoms of AMS, it supports the hypothesis that leukotrienes may be involved in the pathophysiologic state of AMS.
引用
收藏
页码:946 / 951
页数:6
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