Perfluorocarbon nanoparticles enhance reactive oxygen levels and tumour growth inhibition in photodynamic therapy

被引：1023

作者：

Cheng, Yuhao ^{[1
]}

Cheng, Hao ^{[1
]}

Jiang, Chenxiao ^{[1
]}

Qiu, Xuefeng ^{[1
]}

Wang, Kaikai ^{[1
]}

Huan, Wei ^{[1
]}

Yuan, Ahu ^{[1
]}

Wu, Jinhui ^{[1
]}

Hu, Yiqiao ^{[1
,2
]}

机构：

[1] Nanjing Univ, Sch Med, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Jiangsu, Peoples R China

[2] Nanjing Univ, Jiangsu Key Lab Nano Technol, Nanjing 210093, Jiangsu, Peoples R China

来源：

NATURE COMMUNICATIONS | 2015年 / 6卷

关键词：

HYPERBARIC-OXYGEN; IN-VIVO; HYPOXIA; CARCINOMA; CELLS;

D O I：

10.1038/ncomms9785

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Photodynamic therapy (PDT) kills cancer cells by converting tumour oxygen into reactive singlet oxygen (O-1(2)) using a photosensitizer. However, pre-existing hypoxia in tumours and oxygen consumption during PDT can result in an inadequate oxygen supply, which in turn hampers photodynamic efficacy. Here to overcome this problem, we create oxygen self-enriching photodynamic therapy (Oxy-PDT) by loading a photosensitizer into perfluorocarbon nanodroplets. Because of the higher oxygen capacity and longer O-1(2) lifetime of perfluorocarbon, the photodynamic effect of the loaded photosensitizer is significantly enhanced, as demonstrated by the accelerated generation of O-1(2) and elevated cytotoxicity. Following direct injection into tumours, in vivo studies reveal tumour growth inhibition in the Oxy-PDT-treated mice. In addition, a single-dose intravenous injection of Oxy-PDT into tumour-bearing mice significantly inhibits tumour growth, whereas traditional PDT has no effect. Oxy-PDT may enable the enhancement of existing clinical PDT and future PDT design.

引用

页数：8

共 25 条

[1]

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