Heterotopic ossification: Pathophysiology, clinical features, and the role of radiotherapy for prophylaxis

被引：208

作者：

Balboni, Tracy A.

Gobezie, Reuben

Mamon, Harvey J.

机构：

[1] Brigham & Womens Hosp, Dept Radiat Oncol, Boston, MA 02115 USA

[2] Brigham & Womens Hosp, Dept Orthoped Surg, Boston, MA 02115 USA

[3] Harvard Univ, Radiat Oncol Program, Boston, MA 02115 USA

来源：

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 2006年 / 65卷 / 05期

关键词：

heterotopic ossification; heterotopic bone; radiation therapy; prophylaxis;

D O I：

10.1016/j.ijrobp.2006.03.053

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Heterotopic ossification (HO) is a benign condition of abnormal formation of bone in soft tissue. HO is frequently asymptomatic, though when it is more severe it typically manifests as decreased range of motion at a nearby joint. HO has been recognized to occur in three distinct contexts-trauma, neurologic injury, and genetic abnormalities. The etiology of HO is incompletely understood. A posited theory is that HO results from the presence of osteoprogenitor cells pathologically induced by an imbalance in local or systemic factors. Individuals at high risk for HO development frequently undergo prophylaxis to prevent HO formation. The two most commonly employed modalities for prophylaxis are nonsteroidal anti-inflammatory drugs and radiation therapy. This review discusses HO pathophysiology, clinical features, and the role of radiotherapy for prophylaxis. (c) 2006 Elsevier Inc.

引用

页码：1289 / 1299

页数：11

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