Can probiotics modulate human disease by impacting intestinal barrier function?

被引：492

作者：

Bron, Peter A. ^{[1
]}

Kleerebezem, Michiel ^{[2
]}

Brummer, Robert-Jan ^{[3
]}

Cani, Patrice D. ^{[4
]}

Mercenier, Annick ^{[5
]}

MacDonald, Thomas T. ^{[6
]}

Garcia-Rodenas, Clara L. ^{[5
]}

Wells, Jerry M. ^{[2
]}

机构：

[1] NIZO Food Res & BE Basic Fdn, Kernhemseweg 2, NL-6718 ZB Ede, Netherlands

[2] Wageningen Univ, Host Microbe Interact Grp, De Elst 1, NL-6708 WD Wageningen, Netherlands

[3] Univ Orebro, Fac Med & Hlth, Fakultetsgatan 1, SE-70182 Orebro, Sweden

[4] Catholic Univ Louvain, Louvain Drug Res Inst, WELBIO Walloon Excellence Life Sci & BIOtechnol, Metab & Nutr Res Grp, Ave E Mounier,73 B1-73-11, B-1200 Brussels, Belgium

[5] Nestle Res Ctr, Nutr & Hlth Res, Route Jorat 57, CH-1000 Lausanne 26, Switzerland

[6] Queen Mary Univ London, Blizard Inst, Barts & London Sch Med & Dent, Mile End Rd, London E1 4NS, England

来源：

BRITISH JOURNAL OF NUTRITION | 2017年 / 117卷 / 01期

基金：

欧洲研究理事会;

关键词：

Probiotics; Gut microbiota; Gut barrier; Immunity; Gastrointestinal disorders; IRRITABLE-BOWEL-SYNDROME; DIET-INDUCED OBESITY; HIGH-FAT-DIET; RANDOMIZED CONTROLLED-TRIAL; ESCHERICHIA-COLI INFECTION; LACTOBACILLUS-GASSERI SBT2055; LACTIS BB12 SUPPLEMENTATION; INCREASED GUT PERMEABILITY; CASEI STRAIN SHIROTA; NECROTIZING ENTEROCOLITIS;

D O I：

10.1017/S0007114516004037

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 [营养与食品卫生学];

摘要：

Intestinal barrier integrity is a prerequisite for homeostasis of mucosal function, which is balanced to maximise absorptive capacity, while maintaining efficient defensive reactions against chemical and microbial challenges. Evidence is mounting that disruption of epithelial barrier integrity is one of the major aetiological factors associated with several gastrointestinal diseases, including infection by pathogens, obesity and diabetes, necrotising enterocolitis, irritable bowel syndrome and inflammatory bowel disease. The notion that specific probiotic bacterial strains can affect barrier integrity fuelled research in which in vitro cell lines, animal models and clinical trials are used to assess whether probiotics can revert the diseased state back to homeostasis and health. This review catalogues and categorises the lines of evidence available in literature for the role of probiotics in epithelial integrity and, consequently, their beneficial effect for the reduction of gastrointestinal disease symptoms.

引用

页码：93 / 107

页数：15

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