Essential role of KLF5 transcription factor in cell proliferation and differentiation and its implications for human diseases

被引：294

作者：

Dong, Jin-Tang ^{[1
,2
]}

Chen, Ceshi ^{[3
]}

机构：

[1] Emory Univ, Sch Med, Dept Hematol & Med Oncol, Dept Urol, Atlanta, GA 30322 USA

[2] Emory Univ, Sch Med, Winship Canc Inst, Atlanta, GA 30322 USA

[3] Albany Med Coll, Ctr Cell Biol & Canc Res, Albany, NY 12208 USA

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2009年 / 66卷 / 16期

关键词：

KLF5; Proliferation; Survival; Differentiation; Homeostasis; Tumorigenesis; Cardiovascular diseases; KRUPPEL-LIKE FACTOR-5; SMOOTH-MUSCLE-CELLS; GROWTH-FACTOR-BETA; MOUSE LACTOFERRIN GENE; TUMOR-SUPPRESSOR; ANGIOTENSIN-II; FACTOR FAMILY; SELF-RENEWAL; STEM-CELLS; FUNCTIONAL INTERACTION;

D O I：

10.1007/s00018-009-0045-z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

KLF5 (Kruppel-like factor 5) is a basic transcription factor binding to GC boxes at a number of gene promoters and regulating their transcription. KLF5 is expressed during development and, in adults, with higher levels in proliferating epithelial cells. The expression and activity of KLF5 are regulated by multiple signaling pathways, including Ras/MAPK, PKC, and TGF beta, and various posttranslational modifications, including phosphorylation, acetylation, ubiquitination, and sumoylation. Consistently, KLF5 mediates the signaling functions in cell proliferation, cell cycle, apoptosis, migration, differentiation, and stemness by regulating gene expression in response to environment stimuli. The expression of KLF5 is frequently abnormal in human cancers and in cardiovascular disease-associated vascular smooth muscle cells (VSMCs). Due to its significant functions in cell proliferation, survival, and differentiation, KLF5 could be a potential diagnostic biomarker and therapeutic target for cancer and cardiovascular diseases.

引用

页码：2691 / 2706

页数：16

共 142 条

[1]

Positive- and negative-acting Kruppel-like transcription factors bind a transforming growth factor β control element required for expression of the smooth muscle cell differentiation marker SM22α in vivo [J].