Aurora kinases: New targets for cancer therapy

被引：245

作者：

Carvajal, Richard D.

Tse, Archie

Schwartz, Gary K.

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Med, Melanoma Sarcoma Serv, New York, NY 10021 USA

[2] Mem Sloan Kettering Canc Ctr, Gastrointestinal Oncol Serv, New York, NY 10021 USA

[3] Mem Sloan Kettering Canc Ctr, Lab New Drug Dev, Melanoma Sarcoma Serv, New York, NY 10021 USA

来源：

CLINICAL CANCER RESEARCH | 2006年 / 12卷 / 23期

关键词：

D O I：

10.1158/1078-0432.CCR-06-1405

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The Aurora kinase family is a collection of highly related serine/threonine kinases that functions as a key regulator of mitosis. In mammalian cells, Aurora has evolved into three related kinases known as Aurora-A, Aurora-B, and Aurora-C. These kinases are overexpressed in a number of human cancers, and transfection studies have established Aurora-A as a bone fide oncogene. Because Aurora overexpression is associated with malignancy, these kinases have been targeted for cancer therapy. This article reviews the multiple functions of Aurora kinase in the regulation of mitosis and the mitotic checkpoint, the role of abnormal Aurora kinase activity in the development of cancer, the putative mechanisms of Aurora kinase inhibition and its antitumor effects, the development of the first generation of Aurora kinase inhibitors, and prospects for the future of Aurora kinase inhibition in the treatment of cancer.

引用

收藏

页码：6869 / 6875

页数：7

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