Serum lactates correlate with mortality after operations for complex congenital heart disease

被引:78
作者
Cheifetz, IM
Kern, FH
Schulman, SR
Greeley, WJ
Ungerleider, RM
Meliones, JN
机构
[1] DUKE UNIV,MED CTR,DEPT PEDIAT,DUKE CHILDRENS HOSP,DURHAM,NC 27710
[2] DUKE UNIV,MED CTR,DEPT ANESTHESIOL,DUKE CHILDRENS HOSP,DURHAM,NC 27710
[3] DUKE UNIV,MED CTR,DEPT SURG,DUKE CHILDRENS HOSP,DURHAM,NC 27710
关键词
D O I
10.1016/S0003-4975(97)00527-4
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background. The objective of this study was to determine whether serum lactate levels predict mortality in children less than 1 year of age who have undergone cardiopulmonary bypass and operations for complex congenital heart disease. Methods. The initial lactate, maximum lactate, and lactate levels at 4 to 6 hours after operation were analyzed for each of 48 children less than 12 months of age who underwent cardiopulmonary bypass. Results. Data were analyzed for the 6 patients who died and the 42 patients who survived. For the patients who died, the initial postoperative serum lactate, maximum lactate, and 4- to 6-hour lactate levels were significantly higher than those in the patients who survived. All patients with an initial lactate less than 7 mmol/L, a maximum lactate less than 9 mmol/L, or a 4- to 6-hour lactate level less than 4 mmol/L survived to hospital discharge. Conclusions. Serum lactate levels may be a useful predictor of mortality in children less than 1 year of age who have undergone cardiopulmonary bypass. An elevation in serum lactate level after a complex operation for congenital heart disease should be taken as a serious indicator of potential mortality. (C) 1997 by The Society of Thoracic Surgeons.
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收藏
页码:735 / 738
页数:4
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