The immune risk phenotype is associated with IL-6 in the terminal decline stage:: Findings from the Swedish NONA immune longitudinal study of very late life functioning

被引:204
作者
Wikby, Anders
Nilsson, Bengt-Olof [1 ]
Forsey, Rosalyn
Thompson, Julie
Strindhall, Jan
Lofgren, Sture
Ernerudh, Jan
Pawelec, Graham
Ferguson, Frederick
Johansson, Boo
机构
[1] Ryhov Hosp, Dept Infect Dis, S-55185 Jonkoping, Sweden
[2] Jonkoping Univ, Sch Hlth Sci, Dept Nat Sci & Biomed, S-55111 Jonkoping, Sweden
[3] Linkoping Univ, Fac Hlth Sci, Dept Mol & Clin Med, Div Infect Dis, S-58185 Linkoping, Sweden
[4] Unilever Corp Res, Sharnbrook MK44 1LQ, Beds, England
[5] LCG Biosci, Cambridge CB3 7TR, England
[6] Molog Ltd, Sharnbrook MK44 ILQ, Beds, England
[7] Ryhov Hosp, Dept Microbiol, S-55185 Jonkoping, Sweden
[8] Univ Hosp, Dept Mol & Clin Immunol, Div Clin Immunol, S-58185 Linkoping, Sweden
[9] Univ Tubingen, Sch Med, Med Res Ctr, ZMF, D-72072 Tubingen, Germany
[10] Penn State Univ, Coll Agr Sci, Dept Vet Sci, University Pk, PA 16802 USA
[11] Jonkoping Univ, Sch Hlth Sci, Inst Gerontol, S-55111 Jonkoping, Sweden
[12] Univ Gothenburg, Dept Psychol, S-40530 Gothenburg, Sweden
基金
英国医学研究理事会;
关键词
immune risk; T-cells; inflammation; interleukin; 6; survival;
D O I
10.1016/j.mad.2006.04.003
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
In the present NONA immune longitudinal study, we further examine the previously identified T cell immune risk phenotype (IRP), relative inflammatory activity, morbidity and 2-year mortality in very old individuals > 90 years. T-cell subsets as well as the inflammatory markers IL-6, IL-10, C-reactive protein, transthyretin and albumin were evaluated. IRP and low-grade inflammation predicted 57% of observed deaths and 97% of survival over 2 years, and was not significantly affected by individuals' health status, suggesting that the physiological ageing processes of T-cell immunosenescence and low-grade inflammation are of primary importance in late life survival. IRP non-survivors showed only a minor inflammatory activity at baseline, but had in contrast to survivors developed increased activity at follow-up. The results suggest a sequence of stages for IRP individuals that begin with acquisition of CMV infection in earlier life, followed by generation of CD8+CD28- cells to control persistent CMV infection and eventually the development of an IRP Intriguingly, we also found that rare individuals moved out of the IRP category by a process of immune suppression, including increases in IL-6 and IL-10 and decreases in the number of CD3+CD8+CD28- cells. The further characterisation of these exceptional individuals may allow insight into remedial approaches for those who remain in the IRP category until death. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:695 / 704
页数:10
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