AC-magnetic field controlled drug release from magnetoliposomes:: design of a method for site-specific chemotherapy

被引：151

作者：

Babincová, M

Cicmanec, P

Altanerová, V

Altaner, C

Babinec, P

机构：

[1] Comenius Univ, Dept Biophys & Chem Phys, Bratislava 84248, Slovakia

[2] Comenius Univ, Dept Solid State Phys, Bratislava 84248, Slovakia

[3] Slovak Acad Sci, Canc Res Inst, Bratislava 83391, Slovakia

来源：

BIOELECTROCHEMISTRY | 2002年 / 55卷 / 1-2期

关键词：

magnetoliposomes; alternating magnetic field; drug release; doxorubicin; hyperthermia; cancer therapy;

D O I：

10.1016/S1567-5394(01)00171-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Large unilamellar magnetoliposomes (MLs) with encapsulated doxorubicin (DOX) (anticancer drug) were prepared by reverse-phase evaporation. They were exposed to an alternating magnetic field with a frequency of 3.5 MHz and an induction of 1.5 mT produced in three-turn pancake coil. The results showed that magnetoliposomes could be specifically heated to 42 degreesC (phase transition temperature of a used lipid) in a few minutes and during this, the encapsulated doxorubicin is massively released. (C) 2002 Elsevier Science B.V All rights reserved.

引用

页码：17 / 19

页数：3

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