The CHAOS/DIALIGN WWW server for multiple alignment of genomic sequences

被引：43

作者：

Brudno, M

Steinkamp, R

Morgenstern, B ^{[1
]}

机构：

[1] Stanford Univ, Dept Comp Sci, Stanford, CA 94305 USA

[2] Univ Gottingen, Inst Microbiol & Genet, D-37077 Gottingen, Germany

来源：

NUCLEIC ACIDS RESEARCH | 2004年 / 32卷

关键词：

D O I：

10.1093/nar/gkh361

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cross-species sequence comparison is a powerful approach to analyze functional sites in genomic sequences and many discoveries have been made based on genomic alignments. Herein, we present a WWW-based software system for multiple alignment of large genomic sequences. Our server utilizes the previously developed combination of CHAOS and DIALIGN to achieve both speed and alignment accuracy. CHAOS is a fast database search tool that creates a list of local sequence similarities. These are used by DIALIGN as anchor points to speed up the final alignment procedure. The resulting alignment is returned to the user in different formats together with a list of anchor points found by CHAOS. The CHAOS/DIALIGN software is freely available at http://dialign.gobics.de/chaos-dialign-submission.

引用

页码：W41 / W44

页数：4

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