Prediction of deferiprone solubility in aqueous mixtures of ethylene glycol, propylene glycol and polyethylene glycol 400 at various temperatures

被引：23

作者：

Abbasi, Masoumeh ^{[1
]}

Martinez, Fleming ^{[2
]}

Jouyban, Abolghasem ^{[3
,4
,5
]}

机构：

[1] Tabriz Univ Med Sci, Hematol Oncol Res Ctr, Tabriz 51664, Iran

[2] Univ Nacl Colombia, Dept Farm, Grp Invest Farmaceut Fis Quim, Bogota 14490, Colombia

[3] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz 51664, Iran

[4] Tabriz Univ Med Sci, Fac Pharm, Tabriz 51664, Iran

[5] Univ Tehran, Coll Engn, Sch Chem Engn, Pharmaceut Engn Lab, Tehran, Iran

来源：

JOURNAL OF MOLECULAR LIQUIDS | 2014年 / 197卷

关键词：

Deferiprone; Solubility; Prediction; Jouyban-Acree model; van't Hoff equation; Cosolvency; Mixed solvent; PLUS WATER MIXTURES; MINIMUM NUMBER; IRON CHELATION; ETHANOL;

D O I：

10.1016/j.molliq.2014.05.004

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070305 [高分子化学与物理];

摘要：

Solubility of drugs is essential information and no data is available for deferiprone (DFP) in the literature. The solubility of DFP in water, ethylene glycol (EG), propylene glycol (PG) and polyethylene glycol 400 (PEG 400) at 293.2, 298.2, 303.2, 308.2 and 313.2 K is reported and mathematically represented by van't Hoff equation. The solubility of DFP in aqueous binary mixtures of EG, PG and PEG 400 at 298.2 K is determined using the shake flask method and the generated data is used to train the Jouyban-Acree model. The trained versions of the van't Hoff and Jouyban-Acree models are combined to provide predictive models for solubility of DFP in the investigated solvent systems. The mean percentage deviations of the back-calculated solubilities against the corresponding experimental values were 13 and 1.1%, respectively for the mono- and mixed solvent systems. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：171 / 175

页数：5

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