Intravenous corticosteroids in the postpartum period for reduction of acute exacerbations in multiple sclerosis

被引：60

作者：

de Seze, J ^{[1
]}

Chapelotte, M ^{[1
]}

Delalande, S ^{[1
]}

Ferriby, D ^{[1
]}

Stojkovic, T ^{[1
]}

Vermersch, P ^{[1
]}

机构：

[1] Ctr Hosp Reg & Univ Lille, Hop R Salengro, Dept Neurol, F-59037 Lille, France

来源：

MULTIPLE SCLEROSIS JOURNAL | 2004年 / 10卷 / 05期

关键词：

corticosteroid; multiple sclerosis; postpartum; pregnancy; relapses;

D O I：

10.1191/1352458504ms1079sr

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In order to assess the effectiveness of monthly intravenous corticosteroids in reducing childbirth-associated acute exacerbations in multiple sclerosis ( MS), we compared pregnant patients followed up in our MS clinic. During the first period ( 1996 - 1998), 22 patients did not receive any treatment after delivery. During the second period ( 1999 - 2001), following the publication of the PRIMS study, 20 patients were treated monthly with 1 g of intravenous corticosteroids during the six months of the postpartum period. In both groups the relapse rate increased during the first trimester postpartum but it was higher in the untreated group (2 +/- 0.66 [mean +/- SD]) compared with the treated group (0.8 +/- 0.41) ( P = 0.018), suggesting a beneficial effect of monthly intravenous corticosteroids.

引用

页码：596 / 597

页数：2