Molecular characteristics of cocaine-induced cardiomyopathy in rats

被引:18
作者
Besse, S
Assayag, P
Latour, C
Janmot, C
Robert, V
Delcayre, C
Nahas, G
Swynghedauw, B
机构
[1] HOP LARIBOISIERE, INSERM, U127, F-75010 PARIS, FRANCE
[2] HOP LARIBOISIERE, INST FEDERATIF RECH CIRCULAT, F-75010 PARIS, FRANCE
[3] HOP BICHAT, SERV CARDIOL B, F-75018 PARIS, FRANCE
[4] HOP FERNAND WIDAL, LAB TOXICOL CELLULAIRE, F-75010 PARIS, FRANCE
[5] UNIV PARIS 11, URA CNRS 1131, F-91405 ORSAY, FRANCE
[6] NYU, MED CTR, DEPT ANESTHESIOL, NEW YORK, NY 10016 USA
关键词
cocaine; molecular biology; collagen; myosin; atrial natriuretic factor; left ventricular hypertrophy; (rat);
D O I
10.1016/S0014-2999(97)81939-5
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Cocaine abuse induces severe cardiomyopathy. To investigate the molecular effects of acute and prolonged administration of cocaine, mRNAs encoding markers of either mechanical overload, as atrial natriuretic factor (ANF) and alpha- and beta-myosin heavy chains, or fibrosis as type I and III procollagens, were quantitated in the left ventricle of rats 4 h after one injection of cocaine (40 mg/kg, n = 7), or 14 (n = 15) and 28 days (n = 10) after chronic infusion of cocaine (40 mg/kg per day). Plasma cocaine and benzylecgonine concentrations were both significantly augmented during the infusion while plasma levels of triiodothyronine and thyroxin-were lowered. Acute injection of cocaine induced ANF gene expression. Cocaine treatment during 28 days resulted in left ventricular hypertrophy (+ 20% after 24 days, P < 0.05) with normal blood pressure, associated with an accumulation of mRNAs encoding ANF and type I and III collagens (+66% and +55%, P < 0.05). Such a chronic treatment also induced a shift from the cu-to the P-myosin heavy chain gene expression (-40% and +50%, P < 0.05). In conclusion, cocaine activates markers of both hemodynamic overload and fibrosis. Such an activation may result from direct and/or indirect effects of the drug such as myocardial ischemia, mechanical overload and/or hypothyroidism. (C) 1997 Elsevier Science B.V.
引用
收藏
页码:123 / 129
页数:7
相关论文
共 35 条
[1]   CHANGES IN LV PAPILLARY-MUSCLE PERFORMANCE AND MYOSIN COMPOSITION WITH AORTIC-INSUFFICIENCY IN RATS [J].
APSTEIN, CS ;
LECARPENTIER, Y ;
MERCADIER, JJ ;
MARTIN, JL ;
PONTET, F ;
WISNEWSKY, C ;
SCHWARTZ, K ;
SWYNGHEDAUW, B .
AMERICAN JOURNAL OF PHYSIOLOGY, 1987, 253 (05) :H1005-H1011
[2]  
ARNAOUDOV P, 1995, FASEB J, V9, pA369
[3]   Senescent heart compared with pressure overload-induced hypertrophy [J].
Assayag, P ;
Charlemagne, D ;
deLeiris, J ;
Boucher, F ;
Valere, PE ;
Lortet, S ;
Swynghedauw, B ;
Besse, S .
HYPERTENSION, 1997, 29 (01) :15-21
[4]   NORMAL AND HYPERTROPHIED SENESCENT RAT-HEART - MECHANICAL AND MOLECULAR CHARACTERISTICS [J].
BESSE, S ;
ASSAYAG, P ;
DELCAYRE, C ;
CARRE, F ;
CHEAV, SL ;
LECARPENTIER, Y ;
SWYNGHEDAUW, B .
AMERICAN JOURNAL OF PHYSIOLOGY, 1993, 265 (01) :H183-H190
[5]   NONSYNCHRONOUS CHANGES IN MYOCARDIAL COLLAGEN MESSENGER-RNA AND PROTEIN DURING AGING - EFFECT OF DOCA-SALT HYPERTENSION [J].
BESSE, S ;
ROBERT, V ;
ASSAYAG, P ;
DELCAYRE, C ;
SWYNGHEDAUW, B .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 1994, 267 (06) :H2237-H2244
[6]  
BHAMBI B, 1991, AM J PATHOL, V139, P1131
[7]   LEFT-VENTRICULAR HYPERTROPHY ASSOCIATED WITH CHRONIC COCAINE ABUSE [J].
BRICKNER, ME ;
WILLARD, JE ;
EICHHORN, EJ ;
BLACK, J ;
GRAYBURN, PA .
CIRCULATION, 1991, 84 (03) :1130-1135
[8]   SINGLE-STEP METHOD OF RNA ISOLATION BY ACID GUANIDINIUM THIOCYANATE PHENOL CHLOROFORM EXTRACTION [J].
CHOMCZYNSKI, P ;
SACCHI, N .
ANALYTICAL BIOCHEMISTRY, 1987, 162 (01) :156-159
[9]   EXAGGERATED PRESSOR-RESPONSE TO TREADMILL EXERCISE IN CHRONIC COCAINE ABUSERS WITH LEFT-VENTRICULAR HYPERTROPHY [J].
CIGARROA, CG ;
BOEHRER, JD ;
BRICKNER, ME ;
EICHHORN, EJ ;
GRAYBURN, PA .
CIRCULATION, 1992, 86 (01) :226-231
[10]   AORTIC PERFUSION-PRESSURE AS EARLY DETERMINANT OF BETA-ISOMYOSIN EXPRESSION IN PERFUSED HEARTS [J].
DELCAYRE, C ;
KLUG, D ;
VANTHIEM, N ;
MOUAS, C ;
SWYNGHEDAUW, B .
AMERICAN JOURNAL OF PHYSIOLOGY, 1992, 263 (05) :H1537-H1545