Co-infection of HHV-6 and HHV-8 is rare in primary effusion lymphoma

被引：5

作者：

Asou, H

Tasaka, T

Said, JW

Daibata, M

Kamada, N

Koeffler, HP

机构：

[1] Univ Calif Los Angeles, Cedars Sinai Med Ctr, Div Hematol Oncol, Sch Med, Los Angeles, CA 90048 USA

[2] Kochi Med Sch, Dept Med, Kochi 783, Japan

[3] Hiroshima Univ, Dept Canc Cytogenet, Res Inst Radiat Biol & Med, Hiroshima, Japan

来源：

LEUKEMIA RESEARCH | 2000年 / 24卷 / 01期

基金：

美国国家卫生研究院;

关键词：

HHV-6; HHV-8; primary effusion lymphoma;

D O I：

10.1016/S0145-2126(99)00144-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The presence and distribution of Epstein-Barr virus (EBV), as well as human herpesvirus-6 and-8 (HHV-6 and HHV-8) was investigated by polymerase chain reaction in 191 samples from a variety of lymphoproliferative disorders. HHV-6 DNA was detected in 18% (30 of 169) of non-HHV-8 related lymphoproliferative disorders, with the highest frequency in AIDS-related lymphomas (8 of 25, 32%). In contrast, HHV-6 DNA was present in less than 5% (1 of 22) of HHV-8 related lymphoproliferative disorders [21 primary effusion lymphomas (PEL), and 1 cases of Castleman disease]. As compared to HHV-6, EBV DNA was frequently detected in PEL (11 of 19 samples, 58%). This study suggests that transformation to PEL is not enhanced by HHV-6, furthermore HHV-6 and -8 may interfere with each other. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：59 / 61

页数：3

共 18 条

[1] Human herpesvirus 6 (HHV-6)-positive Burkitt's lymphoma: Establishment of a novel cell line infected with HHV-6 [J].