Jekyll-Hyde neurotrophins:: the story of proNGF

被引：101

作者：

Ibáñez, CF ^{[1
]}

机构：

[1] Karolinska Inst, Dept Neurosci, Div Mol Neurobiol, S-17177 Stockholm, Sweden

来源：

TRENDS IN NEUROSCIENCES | 2002年 / 25卷 / 06期

关键词：

D O I：

10.1016/S0166-2236(02)02169-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neurotrophins promote neuronal survival and differentiation by binding to two classes of cell surface receptors: members of the Trk-family receptor tyrosine kinases and p75(NTR), a member of the tumor necrosis factor receptor superfamily. The discoveries that the unprocessed proneurotrophin peptide Is both a preferential high-affinity ligand for p75NTR (with minimal affinity for trkA) and a potent inducer of p75(NTR)-mediated neuronal cell death are likely to change our understanding of neurotrophin physiology and our ability to manipulate their signaling pathways.

引用

页码：284 / 286

页数：3

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