The role of polymorphonuclear leukocytes and oxygen-derived free radicals in experimental acute pancreatitis:: mediators of local destruction and activators of inflammation

被引：117

作者：

Poch, B

Gansauge, F

Rau, B

Wittel, U

Gansauge, S

Nüssler, AK

Schoenberg, M

Beger, HG

机构：

[1] Univ Ulm, Dept Gen Surg, D-89075 Ulm, Germany

[2] Univ Ulm, Div Mol Oncol, D-89075 Ulm, Germany

来源：

FEBS LETTERS | 1999年 / 461卷 / 03期

关键词：

oxygen radical; pancreatitis; polymorphonuclear leukocyte;

D O I：

10.1016/S0014-5793(99)01470-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Using a retrograde infusion sodium taurocholate pancreatitis model in the rat treatment with oxygen radical scavengers or monoclonal anti-ICAM-1 antibody decreased tissue damage and polymorphonuclear leukocytes (PMN) infiltration, Scavengers or anti-ICAM-1 treatment attenuated the activating capacity of blood PMNs following zymosan stimulation. The local production of oxygen free radicals in the pancreas by systemic infusion of hypoxanthine and regional infusion of xanthine oxidase did not induce acute pancreatitis, although an increase of infiltrating PMNs was observed. Our data suggest that oxygen free radicals and infiltrating PMNs aggravate acute pancreatitis and that both are important mediators of local destruction and systemic activation of PMNs. (C) 1999 Federation of European Biochemical Societies.

引用

页码：268 / 272

页数：5

共 22 条

[1]

MEASUREMENT OF CUTANEOUS INFLAMMATION - ESTIMATION OF NEUTROPHIL CONTENT WITH AN ENZYME MARKER [J].