Deficit of quantal release of GABA in experimental models of temporal lobe epilepsy

被引：97

作者：

Hirsch, JC

Agassandian, C

Merchán-Pérez, A

Ben-Ari, Y

DeFelipe, J

Esclapez, M

Bernard, C

机构：

[1] INSERM, U29, F-75014 Paris, France

[2] Univ Europea Madrid, Dept Ciencias Morfol & Fisiol, Madrid 28670, Spain

[3] CSIC, Inst Cajal, E-28002 Madrid, Spain

来源：

NATURE NEUROSCIENCE | 1999年 / 2卷 / 06期

关键词：

D O I：

10.1038/9142

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Because GABA (γ-aminobutyric acid) receptor-mediated inhibition controls the excitability of principal neurons in the brain, deficits in GABAergic inhibition have long been favored to explain seizures. In an experimental model of temporal lobe epilepsy, we have identified a deficit of inhibition in presynaptic GABAergic terminals characterized by decreased GABA quantal activity associated with reduced synaptic vesicle density. This decrease in vesicle number primarily seems to affect the reserve pool, rather than the docked or the readily releasable pool.

引用

页码：499 / 500

页数：2

共 16 条

[1] Operative GABAergic inhibition in hippocampal CA1 pyramidal neurons in experimental epilepsy [J].