Characterization of cationic polyelectrolyte-induced domains in mixed POPG-POPC lipid bilayers via H-2 NMR

被引：24

作者：

Crowell, KJ

MacDonald, PM

机构：

[1] UNIV TORONTO,DEPT CHEM,TORONTO,ON M5S 1A2,CANADA

[2] UNIV TORONTO,ERINDALE COLL,TORONTO,ON M5S 1A2,CANADA

来源：

JOURNAL OF PHYSICAL CHEMISTRY B | 1997年 / 101卷 / 07期

关键词：

D O I：

10.1021/jp963284b

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The interactions of a cationic polyelectrolyte, poly(vinylbenzyltrimethylammonium chloride) (PVTA), with anionic lipid bilayer membranes composed of a mixture of phosphatidylglycerol (POPG) plus phosphatidylcholine (POPC) have been examined using H-2 NMR of choline-deuterated POPC to probe membrane surface electrostatics. PVTA produces distinct membrane domains containing a 1:1 PVTA/POPG cation/anion charge ratio. The remaining PVTA-free domains are depleted with respect to POPG.

引用

收藏

页码：1105 / 1109

页数：5

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