RNA-binding proteins in immune regulation: a focus on CCCH zinc finger proteins

被引：302

作者：

Fu, Mingui ^{[1
,2
]}

Blackshear, Perry J. ^{[3
]}

机构：

[1] Univ Missouri, Dept Basic Med Sci, Sch Med, 2411 Holmes St, Kansas City, MO 64108 USA

[2] Univ Missouri, Shock Trauma Res Ctr, Sch Med, 2411 Holmes St, Kansas City, MO 64108 USA

[3] NIEHS, Signal Transduct Lab, Res Triangle Pk, NC 27709 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2017年 / 17卷 / 02期

基金：

美国国家卫生研究院;

关键词：

TUMOR-NECROSIS-FACTOR; NF-KAPPA-B; AU-RICH ELEMENTS; HELPER T-CELLS; COSTIMULATOR MESSENGER-RNA; CONSTITUTIVE-DECAY ELEMENT; GENOME-WIDE ANALYSIS; STRUCTURAL BASIS; TRISTETRAPROLIN-DEFICIENCY; INFLAMMATORY DISEASE;

D O I：

10.1038/nri.2016.129

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Nearly 60 CCCH zinc finger proteins have been identified in humans and mice. These proteins are involved in the regulation of multiple steps of RNA metabolism, including mRNA splicing, polyadenylation, transportation, translation and decay. Several CCCH zinc finger proteins, such as tristetraprolin (TTP), roquin 1 and MCPIP1 (also known as regnase 1), are crucial for many aspects of immune regulation by targeting mRNAs for degradation and modulation of signalling pathways. In this Review, we focus on the emerging roles of CCCH zinc finger proteins in the regulation of immune responses through their effects on cytokine production, immune cell activation and immune homeostasis.

引用

页码：130 / 143

页数：14

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