Added value of Virtual Touch IQ shear wave elastography in the ultrasound assessment of breast lesions

被引:190
作者
Ianculescu, Victor [1 ]
Ciolovan, Laura Maria [1 ]
Dunant, Ariane [2 ]
Vielh, Philippe [3 ]
Mazouni, Chafika [4 ]
Delaloge, Suzette [5 ]
Dromain, Clarisse [1 ]
Blidaru, Alexandru [6 ]
Balleyguier, Corinne [1 ,7 ]
机构
[1] Dept Radiol, F-94805 Villejuif, France
[2] Inst Gustave Roussy, Dept Stat, F-94805 Villejuif, France
[3] Dept Biopathol, Villejuif, France
[4] Dept Surg, Villejuif, France
[5] Dept Oncol, Villejuif, France
[6] Bucharest Inst Oncol, Dept Surg, Bucharest, Romania
[7] Univ Paris 11, IR4M, UMR 8081, F-91405 Orsay, France
关键词
Breast cancer; Ultrasound; Elastography; Shear wave; Virtual Touch IQ; BIRADS; 4a; US; TECHNOLOGY; EXPERIENCE;
D O I
10.1016/j.ejrad.2014.01.021
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
100231 [临床病理学]; 100902 [航空航天医学];
摘要
Purpose: To determine the diagnostic performance of Acoustic Radiation Force Impulse (ARFI) Virtual Touch IQ shear wave elastography in the discrimination of benign and malignant breast lesions. Materials and methods: Conventional B-mode and elasticity imaging were used to evaluate 110 breast lesions. Elastographic assessment of breast tissue abnormalities was done using a shear wave based technique, Virtual Touch IQ(VTIQ), implemented on a Siemens Acuson S3000 ultrasound machine. Tissue mechanical properties were interpreted as two-dimensional qualitative and quantitative colour maps displaying relative shear wave velocity. Wave speed measurements in m/s were possible at operator defined regions of interest. The pathologic diagnosis was established on samples obtained by ultrasound guided core biopsy or fine needle aspiration. Results: BIRADS based B-mode evaluation of the 48 benign and 62 malignant lesions achieved 92% sensitivity and 62.5% specificity. Subsequently performed VTIQ elastography relying on visual interpretation of the colour overlay displaying relative shear wave velocities managed similar standalone diagnostic performance with 92% sensitivity and 64.6% specificity. Lesion and surrounding tissue shear wave speed values were calculated and a significant difference was found between the benign and malignant populations (Mann-Whitney U test, p < 0.0001). By selecting a lesion cut-off value of 3.31 m/s we achieved 80.4% sensitivity and 73% specificity. Applying this threshold only to BIRADS 4a masses, we reached overall levels of 92% sensitivity and 72.9% specificity. Conclusion: VTIQ qualitative and quantitative elastography has the potential to further characterise B-mode detected breast lesions, increasing specificity and reducing the number of unnecessary biopsies. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:773 / 777
页数:5
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