Three-component synthesis of 3,4-dihydroisoquinoline derivatives

被引：21

作者：

Shklyaev, YV ^{[1
]}

Nifontov, YV ^{[1
]}

机构：

[1] Russian Acad Sci, Ural Branch, Inst Chem Tech, Perm 614000, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2002年 / 51卷 / 05期

关键词：

the Ritter reaction; the Baeyer reaction; 3,3-dimethyl-3,4-dihydroisoquinoline; isobutyraldehyde; nitriles; veratrole; 1,4-dimethoxybenzene; o- and p-xylenes; toluene; three-component synthesis;

D O I：

10.1023/A:1016045103414

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A simple and convenient method for the synthesis of 1-substituted 3,3-dimethyl-3,4-dihydroisoquinolines was developed. The method is based on the [2+2+2] cyclization of alkyl- or alkoxybenzenes with isobutyraldehyde and nitriles.

引用

页码：844 / 849

页数：6