Safety and immunogenicity of a subvirion inactivated influenza A/H5N1 vaccine with or without aluminum hydroxide among healthy elderly adults

被引：55

作者：

Brady, Rebecca C. ^{[1
]}

Treanor, John J. ^{[2
]}

Atmar, Robert L. ^{[3
]}

Keitel, Wendy A. ^{[3
]}

Edelman, Robert ^{[4
]}

Chen, Wilbur H. ^{[4
]}

Winokur, Patricia ^{[5
,6
]}

Belshe, Robert ^{[7
]}

Graham, Irene L. ^{[7
]}

Noah, Diana Lee ^{[8
]}

Guo, Kuo ^{[9
]}

Hill, Heather ^{[9
]}

机构：

[1] Cincinnati Childrens Hosp, Med Ctr, Div Infect Dis, Cincinnati, OH 45229 USA

[2] Univ Rochester, Rochester, NY USA

[3] Baylor Coll Med, Houston, TX 77030 USA

[4] Univ Maryland, Sch Med, Baltimore, MD 21201 USA

[5] VA Med Ctr, Iowa City, IA USA

[6] Univ Iowa, Iowa City, IA USA

[7] St Louis Univ, Sch Med, St Louis, MO USA

[8] So Res Inst, Birmingham, AL 35255 USA

[9] EMMES Corp, Rockville, MD USA

来源：

VACCINE | 2009年 / 27卷 / 37期

关键词：

Avian influenza vaccine; Aluminum hydroxide; Elderly; H5N1; VACCINE; TRIAL;

D O I：

10.1016/j.vaccine.2009.06.057

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A total of 600 healthy adults >= 65 years were randomized to receive 2 vaccinations 1 month apart of a subvirion avian influenza A/H5N1 vaccine containing 3.75, 7.5, 15, or 45 mu g of hemagglutinin (HA) with or without aluminum hydroxide (AIOH). All formulations were safe. Groups given the vaccine with AIOH had more injection site discomfort. Dose-related increases in antibody responses were noted after the second vaccination. Antibody responses to the vaccine were not enhanced by AIOH at any HA dose level. A microneutralization titer >= 40 was observed in 36% and 40% of subjects who received 45 mu g of HA with or without AlOH, respectively. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：5091 / 5095

页数：5

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