The companions: regulatory T cells and gene therapy

被引：6

作者：

Eghtesad, Saman ^{[1
]}

Morel, Penelope A. ^{[3
]}

Clemens, Paula R. ^{[1
,2
]}

机构：

[1] Univ Pittsburgh, Dept Neurol, Sch Med, Pittsburgh, PA 15213 USA

[2] Dept Vet Affairs Med Ctr, Neurol Serv, Pittsburgh, PA USA

[3] Univ Pittsburgh, Dept Immunol, Sch Med, Pittsburgh, PA 15213 USA

来源：

IMMUNOLOGY | 2009年 / 127卷 / 01期

基金：

美国国家卫生研究院;

关键词：

gene therapy; muscle immunology; disease; regulatory T cells; tolerance; CAPACITY ADENOVIRAL VECTOR; FULL-LENGTH DYSTROPHIN; IMMUNE-RESPONSES; DENDRITIC CELLS; TGF-BETA; ADENOASSOCIATED VIRUS; VIRAL VECTORS; TRANSGENE PRODUCTS; FOXP3; EXPRESSION; SKELETAL-MUSCLES;

D O I：

10.1111/j.1365-2567.2009.03069.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Undesired immunological responses to products of therapeutic gene replacement have been obstacles to successful gene therapy. Understanding such responses of the host immune system to achieve immunological tolerance to a transferred gene product is therefore crucial. In this article, we review relevant studies of immunological responses to gene replacement therapy, the role of immunological tolerance mediated by regulatory T cells in down-regulating the unwanted immune responses, and the interrelationship of the two topics.

引用

页码：1 / 7

页数：7

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