Effects of a nitric oxide synthase inhibitor on NMDA receptor function in organotypic hippocampal cultures

被引：4

作者：

Musleh, W ^{[1
]}

Yaghoubi, S ^{[1
]}

Baudry, M ^{[1
]}

机构：

[1] UNIV SO CALIF,HNB 309,PROGRAM NEUROSCI,LOS ANGELES,CA 90089

来源：

BRAIN RESEARCH | 1997年 / 770卷 / 1-2期

关键词：

nitric oxide; N-methyl-D-aspartate; spectrin; long-term potentiation; slice culture;

D O I：

10.1016/S0006-8993(97)00851-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Nitric oxide (NO) has been proposed to trigger long-term potentiation (LTP) at CA3 to CA1 synapses. We previously reported that NO synthesis inhibitors and blockers reduce an electrophysiological index of NMDA receptor activation in acute hippocampal slices. We now show that the NOS inhibitor, N-G-methyl-L-arginine (MLA), also reversibly prevents LTP induction in organotypic hippocampal slices and significantly reduces a biochemical index of NMDA receptor function. These results further indicate that MLA inhibits LTP induction by interfering with NMDA receptor functions. (C) 1997 Elsevier Science B.V.

引用

页码：298 / 301

页数：4

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