New bioactive zinc(II) complexes with peptides and their derivatives: Synthesis, structure, and in vitro insulinomimetic activity

被引:22
作者
Ueda, E
Yoshikawa, Y
Kishimoto, N
Tadokoro, M
Sakurai, H
Kajiwara, N
Kojima, Y
机构
[1] Osaka City Univ, Grad Sch Sci, Dept Chem, Sumiyoshi Ku, Osaka 5588585, Japan
[2] Kyoto Pharmaceut Univ, Dept Analyt & Bioinorgan Chem, Yamashina Ku, Kyoto 6078414, Japan
[3] Kobe Womans Univ, Grad Sch Home Econ, Suma Ku, Kobe, Hyogo 6548585, Japan
关键词
D O I
10.1246/bcsj.77.981
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Four Zn(II) complexes with dipeptides and three new Zn(II) complexes with pseudo-tripeptides were prepared and a complex, [Zn(glythr)(2)](n), was revealed to have a polymeric structure by X-ray structure analysis. The ligand, glythr, acts as a bridging ligand completely, a monodentate oxygen atom of the terminal carboxyl group of threonine residue and a didentate ligand containing the nitrogen and oxygen atoms of glycine one. Because the Zn2+ ion has a distorted six-coordinated octahedral geometry, it binds with two terminal carboxyl groups and two didentate ligands. Also, all Zn(II) complexes were found to have high in vitro insulinomimetic activity compared with that of zinc sulfate, as estimated by the inhibition of free fatty acid release in isolated rat adipocytes that had been treated with epinephrine (adrenalin).
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页码:981 / 986
页数:6
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