Word retrieval in amyotrophic lateral sclerosis: a functional magnetic resonance imaging study

被引:203
作者
Abrahams, S
Goldstein, LH
Simmons, A
Brammer, M
Williams, SCR
Giampietro, V
Leigh, PN
机构
[1] Kings Coll London, Dept Psychol, Inst Psychiat, London SE5 8AF, England
[2] Kings Coll London, Dept Neurol, Inst Psychiat, London SE5 8AF, England
[3] Kings Coll London, Dept Biostat, Inst Psychiat & Comp, London SE5 8AF, England
基金
英国惠康基金;
关键词
motor neuron disease; language functions; executive functions; verbal fluency; naming;
D O I
10.1093/brain/awh170
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The cognitive impairment revealed in some non- demented amyotrophic lateral sclerosis (ALS) patients is characterized by executive dysfunction with widely repeated deficits on tests of verbal (letter) fluency. However, conflicting evidence exists of an impairment on other word retrieval tasks, such as confrontation naming, which do not place heavy demands on executive processes. Previous research has demonstrated intact confrontation naming in the presence of verbal fluency deficits, although naming deficits have been described in other studies. In this investigation, functional MRI (fMRI) techniques were employed to explore whether word retrieval deficits and underlying cerebral abnormalities were specific to letter fluency, which are more likely to indicate executive dysfunction, or were also present in confrontation naming, indicating language dysfunction. Twenty-eight non-demented ALS patients were compared with 18 healthy controls. The two groups were matched for age, intelligence quotient, years of education, and anxiety and depression scores. Two compressed-sequence overt fMRI activation paradigms were employed, letter fluency and confrontation naming, which were developed for use with an older and potentially impaired population. In ALS patients relative to controls, the letter fluency fMRI task revealed significantly impaired activation in the middle and inferior frontal gyri and anterior cingulate gyrus, in addition to regions of the parietal and temporal lobes. The confrontation naming fMRI task also revealed impaired activation in less extensive prefrontal regions, including the inferior frontal gyrus and regions of the temporal, parietal and occipital lobes. These changes were present despite matched performance between patients and controls during each activation paradigm. The pattern of dysfunction corresponded to the presence of cognitive deficits on both letter fluency and confrontation naming in the ALS group. This study provides evidence of cerebral abnormalities in ALS in the network of regions involved in language and executive functions. Moreover, the findings further illustrate the heterogeneity of cognitive and cerebral change in ALS.
引用
收藏
页码:1507 / 1517
页数:11
相关论文
共 81 条
  • [1] Cognitive function in amyotrophic lateral sclerosis
    Abe, K
    Fujimura, H
    Toyooka, K
    Sakoda, S
    Yorifuji, S
    Yanagihara, T
    [J]. JOURNAL OF THE NEUROLOGICAL SCIENCES, 1997, 148 (01) : 95 - 100
  • [2] Relation between cognitive dysfunction and pseudobulbar palsy in amyotrophic lateral sclerosis
    Abrahams, S
    Goldstein, LH
    AlChalabi, A
    Pickering, A
    Morris, RG
    Passingham, RE
    Brooks, DJ
    Leigh, PN
    [J]. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1997, 62 (05) : 464 - 472
  • [3] Functional magnetic resonance imaging of verbal fluency and confrontation naming using compressed image acquisition to permit overt responses
    Abrahams, S
    Goldstein, LH
    Simmons, A
    Brammer, MJ
    Williams, SCR
    Giampietro, VP
    Andrew, CM
    Leigh, PN
    [J]. HUMAN BRAIN MAPPING, 2003, 20 (01) : 29 - 40
  • [4] Frontal lobe dysfunction in amyotrophic lateral sclerosis - A PET study
    Abrahams, S
    Goldstein, LH
    Kew, JJM
    Brooks, DJ
    Lloyd, CM
    Frith, CD
    Leigh, PN
    [J]. BRAIN, 1996, 119 : 2105 - 2120
  • [5] Verbal fluency and executive dysfunction in amyotrophic lateral sclerosis (ALS)
    Abrahams, S
    Leigh, PN
    Harvey, A
    Vythelingum, GN
    Grisé, D
    Goldstein, LH
    [J]. NEUROPSYCHOLOGIA, 2000, 38 (06) : 734 - 747
  • [6] ABRAHAMS S, 2002, COGNITIVE DEFICITS B, P341
  • [7] INVOLVEMENT OF THE AMYGDALA, DENTATE AND HIPPOCAMPUS IN MOTOR-NEURON DISEASE
    ANDERSON, VER
    CAIRNS, NJ
    LEIGH, PN
    [J]. JOURNAL OF THE NEUROLOGICAL SCIENCES, 1995, 129 : 75 - 78
  • [8] FRONTAL AMNESIA AND THE DYSEXECUTIVE SYNDROME
    BADDELEY, A
    WILSON, B
    [J]. BRAIN AND COGNITION, 1988, 7 (02) : 212 - 230
  • [9] Motor neurone disease, dementia and aphasia: coincidence, co-occurrence or continuum?
    Bak, TH
    Hodges, JR
    [J]. JOURNAL OF NEUROLOGY, 2001, 248 (04) : 260 - +
  • [10] Selective impairment of verb processing associated with pathological changes in Brodmann areas 44 and 45 in the motor neurone disease-dementia-aphasia syndrome
    Bak, TH
    O'Donovan, DG
    Xuereb, JH
    Boniface, S
    Hodges, JR
    [J]. BRAIN, 2001, 124 : 103 - 120