Angiolymphoid hyperplasia with eosinophilia: A classic clinical presentation with histologic features of angiosarcoma

BACKGROUND. Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare disease manifested by the proliferation of morphologically distinct endothelial cells. OBJECTIVE. To illustrate by a case report the clinical and varied histopathologic findings of ALHE. METHODS. A 29-year-old woman presented with a clinical picture of ALHE but had several histologic features of angiosarcoma. RESULTS. Management of this patient included repeat biopsies of the lesions, excision of the involved areas, careful histologic examination of the entire specimen, and appropriate follow-up. CONCLUSION. ALHE may present with various histologic features. Knowledge of the spectrum of benign and malignant vascular neoplasms helps manage these challenging cases.