Virus-induced neuronal apoptosis blocked by the herpes simplex virus latency-associated transcript

被引：351

作者：

Perng, GC

Jones, C

Ciacci-Zanella, J

Stone, M

Henderson, G

Yukht, A

Slanina, SM

Hofman, FM

Ghiasi, H

Nesburn, AB

Wechsler, SL

机构：

[1] Cedars Sinai Med Ctr, Burns & Allen Res Inst, Ophthalmol Res Labs, Los Angeles, CA 90048 USA

[2] Univ Nebraska, Ctr Biotechnol, Dept Vet & Biomed Sci, Lincoln, NE 68583 USA

[3] Univ Calif Los Angeles, Sch Med, Dept Pathol, Los Angeles, CA 90025 USA

[4] Univ Calif Los Angeles, Sch Med, Dept Ophthalmol, Los Angeles, CA 90024 USA

来源：

SCIENCE | 2000年 / 287卷 / 5457期

关键词：

D O I：

10.1126/science.287.5457.1500

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Latent infections with periodic reactivation are a common outcome after acute infection with many viruses, The Latency-associated transcript (LAT) gene is required for wild-type reactivation of herpes simplex virus (HSV), However, the underlying mechanisms remain unclear. In rabbit trigeminal ganglia, extensive apoptosis occurred with LAT(-) virus but not with LAT(+) viruses. In addition, a plasmid expressing LAT blocked apoptosis in cultured cells. Thus, LAT promotes neuronal survival after HSV-1 infection by reducing apoptosis.

引用

页码：1500 / 1503

页数：4

共 39 条

[1] The herpes simplex virus type 1 regulatory protein ICP27 is required for the prevention of apoptosis in infected human cells
Aubert, M
Blaho, JA
[J]. JOURNAL OF VIROLOGY, 1999, 73 (04) : 2803 - 2813
[2] Common regulation of apoptosis signaling induced by CD95 and the DNA-damaging stimuli etoposide and γ-radiation downstream from caspase-8 activation
Boesen-de Cock, JGR
Tepper, AD
de Vries, E
van Blitterswijk, WJ
Borst, J
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (20) : 14255 - 14261
[3] CERAMIDE SYNTHASE MEDIATES DAUNORUBICIN-INDUCED APOPTOSIS - AN ALTERNATIVE MECHANISM FOR GENERATING DEATH SIGNALS
BOSE, R
VERHEIJ, M
HAIMOVITZFRIEDMAN, A
SCOTTO, K
FUKS, Z
KOLESNICK, R
[J]. CELL, 1995, 82 (03) : 405 - 414
[4] The latency-related gene of bovine herpesvirus 1 inhibits programmed cell death
Ciacci-Zanella, J
Stone, M
Henderson, G
Jones, C
[J]. JOURNAL OF VIROLOGY, 1999, 73 (12) : 9734 - 9740
[5] Fumonisin B1, a mycotoxin contaminant of cereal grains, and inducer of apoptosis via the tumour necrosis factor pathway and caspase activation
Ciacci-Zanella, JR
Jones, C
[J]. FOOD AND CHEMICAL TOXICOLOGY, 1999, 37 (07) : 703 - 712
[6] CONTROL OF PROGRAMMED CELL-DEATH BY THE BACULOVIRUS GENES P35 AND IAP
CLEM, RJ
MILLER, LK
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (08) : 5212 - 5222
[7] Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate
Cuvillier, O
Pirianov, G
Kleuser, B
Vanek, PG
Coso, OA
Gutkind, JS
Spiegel, S
[J]. NATURE, 1996, 381 (6585) : 800 - 803
[8] TRANSCRIPTIONAL TRANSACTIVATION FUNCTIONS LOCALIZED TO THE GLUCOCORTICOID RECEPTOR-N TERMINUS ARE NECESSARY FOR STEROID INDUCTION OF LYMPHOCYTE APOPTOSIS
DIEKEN, ES
MIESFELD, RL
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1992, 12 (02) : 589 - 597
[9] The region of the herpes simplex virus type 1 LAT gene involved in spontaneous reactivation does not encode a functional protein
Drolet, BS
Perng, GC
Cohen, J
Slanina, SM
Yukht, A
Nesburn, AB
Wechsler, SL
[J]. VIROLOGY, 1998, 242 (01) : 221 - 232
[10] Cleavage of poly(ADP-ribose) polymerase: a sensitive parameter to study cell death
Duriez, PJ
Shah, GM
[J]. BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE, 1997, 75 (04): : 337 - 349

← 1 2 3 4 →