Gestational diabetes mellitus and gene mutations which affect insulin secretion

被引:22
作者
Allan, CJ
Argyropoulos, G
Bowker, M
Zhu, JG
Lin, PM
Stiver, K
Golichowski, A
Garvey, WT
机构
[1] MED UNIV S CAROLINA,DEPT MED,DIV ENDOCRINOL,CHARLESTON,SC 29425
[2] MED UNIV S CAROLINA,DEPT MED,DIV ENDOCRINOL DIABET & MED GENET,CHARLESTON,SC 29425
[3] RALPH H JOHNSON VET AFFAIRS MED CTR,CHARLESTON,SC 29425
[4] INDIANA UNIV,SCH MED,DEPT OBSTET & GYNECOL,INDIANAPOLIS,IN 46202
关键词
gestational diabetes; gene mutations; impaired insulin secretion; glucokinase; tRNA(leu); mitochondrial DNA;
D O I
10.1016/S0168-8227(97)00042-9
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We investigated whether genetic mutations known to impair insulin secretion and glucose tolerance are operative in a group of American women with gestational diabetes mellitus. Study groups were comprised of elderly non-diabetic controls (n = 55) with normal glucose tolerance and patients with gestational diabetes (n = 50), together with one family with maturity-onset diabetes of the young (three controls and three affected). No mutations were detected in any exon of the human glucokinase gene or the mitochondrial tRNA(Leu(UUR)) gene by single strand conformational analysis; and direct exon sequencing. Also, X-2 analysis showed no significant association with gestational diabetes for a polymorphism at position -30 (G --> A) of the beta-cell-specific glucokinase gene promoter. We have determined that glucokinase and mitochondrial tRNA(Leu(UUR)) gene mutations, which are known to impair insulin secretion are relatively uncommon and do not constitute a large component of genetic risk for gestational diabetes in the study population. (C) 1997 Elsevier Science Ireland Ltd.
引用
收藏
页码:135 / 141
页数:7
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