Lessons learned from the development of an Abl tyrosine kinase inhibitor for chronic myelogenous leukemia

被引:697
作者
Druker, BJ
Lydon, NB
机构
[1] Oregon Hlth & Sci Univ, Div Hematol & Med Oncol, Portland, OR 97201 USA
[2] Kinetix Pharmaceut Inc, Medford, MA 02155 USA
关键词
D O I
10.1172/JCI9083
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
[No abstract available]
引用
收藏
页码:3 / 7
页数:5
相关论文
共 28 条
[1]   TRANSLOCATION OF C-ABL ONCOGENE CORRELATES WITH THE PRESENCE OF A PHILADELPHIA-CHROMOSOME IN CHRONIC MYELOCYTIC-LEUKEMIA [J].
BARTRAM, CR ;
DEKLEIN, A ;
HAGEMEIJER, A ;
VANAGTHOVEN, T ;
VANKESSEL, AG ;
BOOTSMA, D ;
GROSVELD, G ;
FERGUSONSMITH, MA ;
DAVIES, T ;
STONE, M ;
HEISTERKAMP, N ;
STEPHENSON, JR ;
GROFFEN, J .
NATURE, 1983, 306 (5940) :277-280
[2]   THE CHRONIC MYELOGENOUS LEUKEMIA SPECIFIC P210-PROTEIN IS THE PRODUCT OF THE BCR/ABL HYBRID GENE [J].
BEN-NERIAH, Y ;
DALEY, GQ ;
MESMASSON, AM ;
WITTE, ON ;
BALTIMORE, D .
SCIENCE, 1986, 233 (4760) :212-214
[3]  
Beran M, 1998, CLIN CANCER RES, V4, P1661
[4]  
Buchdunger E, 1996, CANCER RES, V56, P100
[5]   SELECTIVE-INHIBITION OF THE PLATELET-DERIVED GROWTH-FACTOR SIGNAL-TRANSDUCTION PATHWAY BY A PROTEIN-TYROSINE KINASE INHIBITOR OF THE 2-PHENYLAMINOPYRIMIDINE CLASS [J].
BUCHDUNGER, E ;
ZIMMERMANN, J ;
METT, H ;
MEYER, T ;
MULLER, M ;
REGENASS, U ;
LYDON, NB .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (07) :2558-2562
[6]   CGP 57148, a tyrosine kinase inhibitor, inhibits the growth of cells expressing BCR-ABL, TEL-ABL, and TEL-PDGFR fusion proteins [J].
Carroll, M ;
OhnoJones, S ;
Tamura, S ;
Buchdunger, E ;
Zimmermann, J ;
Lydon, NB ;
Gilliland, DG ;
Druker, BJ .
BLOOD, 1997, 90 (12) :4947-4952
[7]   EXPRESSION OF A DISTINCTIVE BCR-ABL ONCOGENE IN PH1-POSITIVE ACUTE LYMPHOCYTIC-LEUKEMIA (ALL) [J].
CLARK, SS ;
MCLAUGHLIN, J ;
TIMMONS, M ;
PENDERGAST, AM ;
BEN-NERIAH, Y ;
DOW, LW ;
CRIST, W ;
ROVERA, G ;
SMITH, SD ;
WITTE, ON .
SCIENCE, 1988, 239 (4841) :775-777
[8]   INDUCTION OF CHRONIC MYELOGENOUS LEUKEMIA IN MICE BY THE P210BCR/ABL GENE OF THE PHILADELPHIA-CHROMOSOME [J].
DALEY, GQ ;
VANETTEN, RA ;
BALTIMORE, D .
SCIENCE, 1990, 247 (4944) :824-830
[9]   The tyrosine kinase inhibitor CGP57148B selectively inhibits the growth of BCR-ABL-positive cells [J].
Deininger, MWN ;
Goldman, JM ;
Lydon, N ;
Melo, JV .
BLOOD, 1997, 90 (09) :3691-3698
[10]   Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells [J].
Druker, BJ ;
Tamura, S ;
Buchdunger, E ;
Ohno, S ;
Segal, GM ;
Fanning, S ;
Zimmermann, J ;
Lydon, NB .
NATURE MEDICINE, 1996, 2 (05) :561-566