Redox-mediated signal transduction by cardiovascular Nox NADPH oxidases

被引：65

作者：

Brandes, Ralf P. ^{[1
]}

Weissmann, Norbert ^{[2
]}

Schroeder, Katrin ^{[1
]}

机构：

[1] Goethe Univ Frankfurt, Inst Kardiovaskulare Physiol, D-60590 Frankfurt, Germany

[2] Univ Giessen, Giessen Univ Lung Ctr, D-35390 Giessen, Germany

来源：

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY | 2014年 / 73卷

关键词：

NADPH oxidase; Redox-regulation; Oxidative stress; Hydrogen peroxide; Thiol; Nitric oxide; SMOOTH-MUSCLE-CELLS; OXYGEN SPECIES GENERATION; NA+-K+ PUMP; NF-KAPPA-B; ANGIOTENSIN-II; INDEPENDENT ACTIVATION; OXIDATIVE MODIFICATION; TYROSINE-PHOSPHATASE; S-GLUTATHIOLATION; NAD(P)H OXIDASE;

D O I：

10.1016/j.yjmcc.2014.02.006

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

The only known function of the Nox family of NADPH oxidases is the production of reactive oxygen species (ROS). Some Nox enzymes show high tissue-specific expression and the ROS locally produced are required for synthesis of hormones or tissue components. In the cardiovascular system, Nox enzymes are low abundant and function as redox-modulators. By reacting with thiols, nitric oxide (NO) or trace metals, Nox-derived ROS elicit a plethora of cellular responses required for physiological growth factor signaling and the induction and adaptation to pathological processes. The interactions of Nox-derived ROS with signaling elements in the cardiovascular system are highly diverse and will be detailed in this article, which is part of a Special Issue entitled "Redox Signalling in the Cardiovascular System". (c) 2014 Elsevier Ltd. All rights reserved:

引用

页码：70 / 79

页数：10

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